![]() In about 50% of post-menopausal women the ovaries continue to secrete some T but little delta 4-A or DHA. The normal ovary does not secrete significant amounts of DHAS. In the peri-ovulatory period the secretion rate of delta 4-A can rise to 3-3.5 mg/day but there appears to be little change in the secretion of DHA and T. ![]() The ovarian secretion rate in the follicular phase is 1-2 mg/day for DHA, 1-1.5 mg/day for delta 4-A and about 50 micrograms/day for T. Adrenalin hormone is released mainly through the activation of nerves connected to the adrenal glands, which trigger the secretion of adrenalin hormone and thus increase the levels of adrenaline in the blood. Androgen secretion from the ovary arises in part from the theca cells of the follicle, the corpus luteum and the stromal cells, under LH control, and will vary somewhat during the normal menstrual cycle. THe adrenal secretion rates are in the range of 7-14 mg/day for DHAS, 3-4 mg/day for DHA, 1-1.5 mg/day for delta 4-A and 50 micrograms/day for T. This secretion is under ACTH control, at least in part, but apparently also under control of another pituitary polypeptide tentatively called 'adrenal androgen secretory hormone'. Post-pubertally, the adrenal secretes DHAS, DHA, delta 4-A and T from the reticularis and probably the fasciculata. However the secretion of DHAS declines markedly after birth and until puberty there is little androgen secretion by either the adrenal or the ovary. The fetal ovary is not very active but the fetal adrenal is an important source of DHAS. ![]() ![]() Both the adrenal and the ovary contain the biosynthetic pathways necessary for androgen synthesis and secretion. ![]()
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